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Original Research Article | OPEN ACCESS

Kaempferol inhibits the proliferation and migration of Epstein-Barr virus-positive diffuse large B-cell lymphoma cells

Suli Lu1, Zhen Wang1, Dae-jung Yang2

1Department of Medicine, Hunan Polytechnic of Environment and Biology, Hengyang City, Hunan Province 421005, China; 2Department of Physical Therapy, Sehan University, Mokpo City, Jeollanam-do, 58447, Republic of Korea.

For correspondence:-  Dae-jung Yang   Email: pt6226@sehan.ac.kr   Tel:+821066116264

Accepted: 2 February 2024        Published: 29 February 2024

Citation: Lu S, Wang Z, Yang D. Kaempferol inhibits the proliferation and migration of Epstein-Barr virus-positive diffuse large B-cell lymphoma cells. Trop J Pharm Res 2024; 23(2):257-262 doi: 10.4314/tjpr.v23i2.4

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To assess the effect of kaempferol on the growth, apoptosis, and motility of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) cells, and to elucidate its mechanism of action.
Methods: Human DLBCL cells were used to generate EBV-positive (EBV +) cell line Pfeiffer. CCK-8, colony formation, flow cytometry (FCM), and immunoblot assays were employed to determine the effects of kaempferol on the growth and apoptosis of EBV + DLBCL cells. Cell motility was evaluated by Transwell and immunoblot assays. Immunoblot assay was further conducted to unravel the mechanism of action.
Results: Kaempferol inhibited the growth of EBV + DLBCL cells. It also enhanced the apoptosis of EBV + DLBCL cells, but inhibited the motility of the cells. Furthermore, kaempferol inhibited PI3K/AKT axis, thereby suppressing DLBCL.
Conclusion: Kaempferol inhibits the growth and motility of EBV + DLBCL cells via PI3K/AKT axis. It is therefore a potential drug for the treatment of DLBCL.

Keywords: Epstein-Barr virus (EBV), Diffuse large B-cell lymphoma (DLBCL), Kaempferol, Apoptosis, PI3K/AKT

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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