Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of propofol and remifentanil combination for controlled hypotension during anesthesia in pediatric nasal endoscopic surgery

Siyao Li¹, Min Ye², Xingxu Wang³

¹Department of Anesthesiology, The 6th Medical Center of the PLA General Hospital, Beijing, China; ²Department of Anesthesia, Jiang Qiao Hospital, Jiading District, Shanghai, China; ³The First People's Hospital of Guannan County, Lianyungang, China.

For correspondence:- Xingxu Wang Email: q277297474@126.com

Accepted: 2 February 2024 Published: 29 February 2024

Citation: Li S, Ye M, Wang X. Evaluation of propofol and remifentanil combination for controlled hypotension during anesthesia in pediatric nasal endoscopic surgery. Trop J Pharm Res 2024; 23(2):363-369 doi: 10.4314/tjpr.v23i2.16

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the safety and efficacy of propofol in combination with remifentanil for controlled hypotension during pediatric nasal endoscopic surgery.

Methods: The study involved 30 patients who underwent controlled hypotension measures with remifentanil during the operation (study group), and 30 patients who did not receive controlled hypotension measures (control group). Various parameters including vital signs, operation time, intraoperative bleeding, surgical field quality, anesthesia quality, postoperative recovery time, adverse reaction rate, pain scores, and serum C-reactive protein levels were compared between the two groups.

Results: The results revealed a significant decrease in mean arterial pressure and heart rate in the study group during the operation compared to control group. Moreover, study group exhibited improved operation time, reduced intraoperative bleeding, and better surgical field quality compared to control group. Pain scores and serum C-reactive protein levels were also lower in the study group. However, there were no significant differences in recovery time, anesthesia quality, postoperative adverse reaction rate, or cognitive function between the two groups.

Conclusion: Propofol in combination with remifentanil for controlled hypotension is a safe and effective anesthesia approach for pediatric nasal endoscopic surgery. Future studies will require larger sample size from different study centers to improve the robustness of the findings of this study.

Keywords: Children, Nasal endoscopy, Adenoidectomy, Snoring, General anesthesia, Propofol, Remifentanil, Controlled hypotension