Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of target-controlled infusion of remifentanil in combination with propofol on anesthesia and endotracheal intubation response in patients undergoing surgical aneurysm clipping

Shijie Yang, Yaqin Wu, Jingli Chen, Shenghua Li

Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province 430014, China;

For correspondence:- Shenghua Li Email: lishenghua0011@hotmail.com

Accepted: 4 February 2024 Published: 29 February 2024

Citation: Yang S, Wu Y, Chen J, Li S. Effect of target-controlled infusion of remifentanil in combination with propofol on anesthesia and endotracheal intubation response in patients undergoing surgical aneurysm clipping. Trop J Pharm Res 2024; 23(2):457-463 doi: 10.4314/tjpr.v23i2.28

© 2024 The authors.
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Abstract

Purpose: To investigate the effect of target-controlled infusion of remifentanil in combination with propofol on anesthesia and endotracheal intubation response in patients undergoing surgical aneurysm clipping.

Methods: The clinical data of 106 patients undergoing surgical aneurysm clipping at the Central Hospital of Wuhan, Wuhan City, China from September 2020 to December 2022 were retrospectively analyzed. Subjects in control group were given fentanyl intravenous infusion anesthesia while study group was treated with target-controlled infusion anesthesia of remifentanil combined with propofol. Hemodynamics and blood-gas indices were evaluated before anesthesia (T1), immediately after endotracheal intubation (T2) and at extubation (T3). The incidence of anesthesia-related complications was determined.

Results: In study group, the agitation score was decreased compared to that of control group, while the Ramsay sedation score was increased (p < 0.05). The incidence of cough during endotracheal catheter indwelling and extubation was 7. 27 % in study group, which was less than 21. 57 % in control group (p < 0.05). The cough score of study group was also reduced (p < 0.05). There were no significant differences in the SpO₂ and PetCO₂ values between the two groups at different times (p > 0.05). Furthermore, the mean arterial pressure at T2 and T3 was upregulated and heart rate (HR) was downregulated in study group (p < 0.05). Recovery time of spontaneous respiration, time of eye-opening and extubation in study group were decreased compared to control group (p < 0.05).

Conclusion: Target-controlled infusion of remifentanil in combination with propofol improves anesthetic effect in patients undergoing surgical aneurysm clipping, reduces tracheal intubation reaction, maintains hemodynamic stability and improves recovery quality of patients. Future study will be required to evaluate the efficacy and optimal effective concentration in a diverse population.

Keywords: Surgical aneurysm clipping, Remifentanil, Propofol, Target-controlled infusion, Anesthesia effect, Tracheal intubation response