Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Distribution and antimicrobial susceptibility of pathogenic micro-organisms in pediatric urinary tract infections

Jing Leng, Jie Yang

Danyang People’s Hospital of Jiangsu Province, Nantong University Affiliated Dangyang Hospital, Clinical Laboratory, China;

For correspondence:- Jie Yang Email: kwqfk77557@tom.com

Accepted: 30 June 2024 Published: 31 July 2024

Citation: Leng J, Yang J. Distribution and antimicrobial susceptibility of pathogenic micro-organisms in pediatric urinary tract infections. Trop J Pharm Res 2024; 23(7):1119-1125 doi: 10.4314/tjpr.v23i7.10

© 2024 The authors.
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Abstract

Purpose: To investigate the prevalence and distribution of pathogenic microorganisms and antimicrobial susceptibility in pediatric urinary tract infections (UTIs).

Methods: 150 pediatric patients with UTI diagnosed and treated in Danyang People’s Hospital of Jiangsu Province, China between January 2020 and December 2022 were enrolled. The distribution of pathogenic microorganisms was analyzed using microbial culture and antimicrobial susceptibility test results obtained for major gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia). Based on adherence to antimicrobial susceptibility data, patients were divided into study (adhered to antimicrobial susceptibility) and control groups (did not adhere to antimicrobial susceptibility). The efficacy of treatments was compared.

Results: A total of 184 strains of pathogenic microorganisms were cultured from the urine of the 150 patients. Gram-negative bacteria accounted for 75.54 %, while gram-positive bacteria accounted for 24.46 %. Frequently encountered strains were Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis. Major gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa showed higher sensitivity to cefotaxime, imipenem, furantoin, cefepime-tazobactam and amikacin, while major Gram-positive bacteria like Enterococcus faecalis showed higher sensitivity to vancomycin, imipenem and ampicillin-sulbactam. Clinical efficacy in the study group was significantly higher (p < 0.05) compared to the control group.

Conclusion: The distribution of pathogenic microorganisms in pediatric UTIs is diverse, with Gram-negative bacteria being the most common pathogens. Further studies should expand the sample size and broaden the scope of study subjects to comprehensively investigate the distribution of pathogenic microorganisms in pediatric urinary tract infections.

Keywords: Pediatric urinary tract infection, Pathogenic microorganisms, Antimicrobial susceptibility testing, Antimicrobial treatment