YouWei Guo1,2,
WeiMing Xu1,2,
Bin Liu1,2,
Shuai Xu1,
Wei Wang1,
XingDa Guo1,
Gang Liu1,2 
,
EnHeJiRiGaLa 3
For correspondence:- Gang Liu Email: liugang761211@hotmail.com
Accepted: 25 July 2024 Published: 31 August 2024
Citation: Guo Y, Xu W, Liu B, Xu S, Wang W, Guo X, et al. Effect of mecobalamin dispersible tablets and surgical treatment on nerve conduction velocity and skin sympathetic reflex in cervical spondylotic radiculopathy patients. Trop J Pharm Res 2024; 23(8):1315-1321 doi: 10.4314/tjpr.v23i8.11
© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of mecobalamin dispersible tablets and surgical treatment on nerve conduction velocity and skin sympathetic reflex in patients with cervical spondylotic radiculopathy (CSR).
Methods: 82 patients diagnosed with CSR between February 2019 and January 2022 in Inner Mongolia Medical University School of Basic Medicine, Hohhot City, China were randomized into control and study groups comprising 41 patients each. The control group was treated with anterior cervical diskectomy and fusion, while the study group was treated with mecobalamin dispersible tablets in addition to surgery. Efficacy was assessed 3 months after surgery.
Results: Efficacy in the study group was significantly higher than in the control group (p < 0.05). Furthermore, the study group had significantly greater motor and sensory nerve conduction velocity of the median and ulnar nerve as well as reduced initial wave latency (p < 0.05). Scores of subjective symptoms, clinical signs, and life-work-social adaptability were significantly higher in the study group than in the control group (p < 0.05). Range of motion of the neck significantly improved and brain-derived neurotrophic factor and glial neurotrophic factor were significantly increased in the study group compared to control group (p < 0.05).
Conclusion: Mecobalamin dispersible tablets in combination with surgery improve nerve conduction velocity, skin sympathetic reflex function, neurotrophic factor level, cervical motion, and cervical spine function in patients with CSR. Multicenter long-term controlled studies with larger sample sizes are required in future studies.
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