Kunfeng He,
Jun Liao,
Jun Du,
Jiafei Yang,
Yingquan Zhuo,
Huajian Gu 
For correspondence:- Huajian Gu Email: zhaoyaree@sina.com
Accepted: 29 July 2024 Published: 31 August 2024
Citation: He K, Liao J, Du J, Yang J, Zhuo Y, Gu H. Effect of intestinal microecological agents on perioperative gastrointestinal function and complications in congenital megacolon. Trop J Pharm Res 2024; 23(8):1323-1329 doi: 10.4314/tjpr.v23i8.12
© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the efficacy of intestinal microecological agents in enhancing gastrointestinal function in perioperative period of Hirschsprung disease.
Methods: 30 cases with surgically managed Hirschsprung in The Affiliated Hospital of Guizhou Medical University, China between March 2020 and March 2022, were randomized into control and study groups comprising 15 patients each. Both groups underwent laparoscopic-assisted megacolon-modified Swenson radical surgery. Control group received preoperative oral cefaclor suspension for three days, while the study group received Bacillus subtilis diphtheriae granules in addition to preoperative oral cefaclor suspension for four days prior to surgery, and continued from day 10 to day 24 after surgery. Symptoms, efficacy, safety, intestinal microecology, gastrointestinal function, inflammation, and nutrition were assessed upon admission, and 10 days after surgery. Postoperative complications were compared.
Results: Bacterial counts in both groups increased significantly on Day 10 after surgery compared to the counts at admission (p < 0.05). The study group exhibited significantly higher counts compared to the control group (p < 0.05). The bacilli-to-cocci ratio in the study group did not change significantly (p > 0.05). Nutritional status was significantly higher in the study group compared to control group 10 days after surgery (p < 0.05). Furthermore, the incidence of small bowel colitis was lower in the study group compared to control group. There was no significant difference in the incidence of complications in both groups (p > 0.05).
Conclusion: Perioperative use of intestinal microecological agents effectively corrects dysbiosis, improves gastrointestinal function, regulates nutritional indices, and reduces postoperative complications in patients with Hirschsprung disease. Future studies involving a larger number of participants from different ethnic extractions would be required to improve the quality of results obtained from this investigation.
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