Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Impact of human papillomavirus (HPV) prophylactic vaccination on infertile male patients with HPV semen infection: A systematic review

Mohammed Kanan¹ , Nawaf Alotaibi², Rawan Alshehri³, Arwa Alhoqail⁴, Kawther Abdulazim⁵

¹Department of Clinical Pharmacy, King Fahad Medical City, Riyadh 12211, Saudi Arabia; ²Department of Clinical Pharmacy, Northern Border University, Rafha 73213, Saudi Arabia; ³Department of Medicine, Taif University, Taif 21944, Saudi Arabia; ⁴Department of Geriatric Medicine, Ministry of National Guard Health Affairs, Riyadh 12211, Saudi Arabia; ⁵Department of Nursing, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia.

For correspondence:- Mohammed Kanan Email: kanan101@outlook.com

Accepted: 31 July 2024 Published: 31 August 2024

Citation: Kanan M, Alotaibi N, Alshehri R, Alhoqail A, Abdulazim K. Impact of human papillomavirus (HPV) prophylactic vaccination on infertile male patients with HPV semen infection: A systematic review. Trop J Pharm Res 2024; 23(8):1379-1385 doi: 10.4314/tjpr.v23i8.20

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To characterize the impact of prophylactic vaccination against human papillomavirus (HPV) on infertile male patients with HPV semen infection.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. First, an electronic search of PubMed, Scopus and Web of Science databases from 2018 to 2023 using specific keywords was conducted. Thereafter, three authors independently screened the articles and removed duplicates. Following the acquisition of the papers, a quality analysis was conducted using the Strengthening the Reporting of Observational Studies in Epidemiology Criteria.

Results: A total of 41 pregnancies were reported out of which 15.3 % were in control group and 38.9 % were in the vaccinated group (p < 0.05). The clearance of HPV DNA correlated significantly with a serum HPV antibody titer of ≥ 1:125 at initial examination. Compared with individuals who tested negative for HPV, those who became seropositive at 12 (p = 0.039), 18 (p = 0.034) and 24 months (p = 0.034) had fewer multiple infections and a lower incidence of HPV infection in semen.

Conclusion: Examination of the association between male fertility and HPV reveals a clear correlation between HPV infection and male infertility, specifically asthenospermia and oligoasthenospermia. Further studies are needed to fully understand the benefits of this approach in managing male infertility.

Keywords: Human papillomavirus, HPV vaccine, Prophylactic vaccination, Infertility, Semen