Xuezhao Li, Ming Fu, Xiang Liu, Zhiyin E, Cong Wang, Fangqiu Tian

For correspondence:-  Fangqiu Tian   Email: tianfangqiu2023@163.com

Received: 6 December 2023        Accepted: 19 September 2024        Published: 30 October 2024

Citation: Li X, Fu M, Liu X, E Z, Wang C, Tian F. Effect of total hip arthroplasty combined with alendronate sodium for the treatment of geriatric patients with femoral neck fracture. Trop J Pharm Res 2024; 23(10):1693-1699 doi: 10.4314/tjpr.v23i10.14

© 2024 The authors.
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Abstract

Purpose: To study the effect of total hip arthroplasty (THA) combined with alendronate sodium for the treatment of geriatric patients with femoral neck fracture (FNF). Methods: A retrospective analysis was conducted on 100 geriatric patients with FNF treated at Heilongjiang Provincial Hospital, Harbin, China from August 2020 to August 2022. The patients were divided into control (n = 45) and study groups (n = 55). Control group received THA, while the study group received THA plus oral alendronate sodium (10 mg daily for three months). Bone mineral density (BMD), tartrate-resistant acid phosphatase (TRAP), serum osteosclerosis (SOST) and insulin-like growth factor 1 (IGF-1) levels were compared between groups before and 3 months after treatment. Results: Study group exhibited significantly higher total effective rate compared to control group (p < 0.05). After treatment, the study group exhibited significantly increased BMD and IGF-1 levels and decreased SOST and TRAP levels compared to control group (p < 0.05). Both groups showed significant changes in SOST and IGF-1 levels, with a decrease in SOST and an increase in IGF-1 (p < 0.05). Furthermore, the study group demonstrated significant increase in BMD but a decrease in TRAP level after treatment (p < 0.05). Conclusion: The combination of THA and alendronate sodium significantly enhances BMD and promotes healing in geriatric patients with FNF. Additional studies should address the challenge of small sample size to improve reliability and generalizability of these findings.