Duygu Felek¹, Onur ?lkay Dinçer²

For correspondence:-  Onur Dinçer   Email: d.kocamemik@gmail.com   Tel:+90-5373015777

Received: 14 May 2024        Accepted: 2 November 2024        Published: 29 November 2024

Citation: Felek D, Dinçer O?. Effect of micropancreatic enzyme on biochemical profile in patients who have undergone cholecystectomy. Trop J Pharm Res 2024; 23(11):1895-1900 doi: 10.4314/tjpr.v23i11.13

© 2024 The authors.
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Abstract

Purpose: To determine the effectiveness of micropancreatic enzymes on biochemical profiles in patients who have undergone cholecystectomy. Method: A total of 122 patients with pancreatic exocrine insufficiency who visited the outpatient clinic of Sorgun State Hospital, Yozgat, Turkey and had undergone cholecystectomy in the last three months were assigned to study and control groups. Study group (n = 72) received micro pancreatic enzyme mixture for at least 4 weeks within 3 months of cholecystectomy. Control group (n = 50) with a history of cholecystectomy did not use any digestive aids or micro pancreatic enzyme mixture during the same period. Pancreatic insufficiency, water consumption, Vit D, B12, calcium, and lipid profiles were compared in both groups. Results: Severity of pancreatic exocrine insufficiency was significantly mild in study group compared to control group (p < 0.05). In patients who had undergone cholecystectomy, total cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels after at least 6 weeks were significantly lower in study group compared to control group (p < 0.05). Conclusion: Micropancreatic enzyme improves pancreatic function, and lowers lipid levels in patients who have undergone cholecystectomy. A prospective, randomized controlled study will be useful in determining the appropriate dosage and duration of use which provides symptomatic relief and biochemical improvement in patients who have undergone cholecystectomy.