Guner Kilic¹ , Gulce Ecem Kilic², Nuket Bayram Kayar³, Ozan Durmaz⁴, Adnan Ozkahraman⁴, Sevki Konur⁵, Ramazan Dertli⁶, Yusuf Kayar⁷

Abstract

Purpose: To assess the effectiveness, safety and adverse effects of treatment regimen combining amoxicillin, gemifloxacin and rabeprazole for eradicating Helicobacter pylori in adult population. Methods: A total of 211 patients comprising 33 patients (15.6 %) from the older adult group and 178 patients (84.4 %) from the younger adult group who visited Van Training and Research Hospital, Turkey were included in this study. Treatment, made up of amoxicillin (1000 mg) and rabeprazole (20 mg), was administered 12 hourly and gemifloxacin (320 mg) once daily to all patients for 7 days. Thereafter, patients were evaluated for H. pylori eradication by examining antigens in feces (immunochromatographically based, qualitatively), drug compliance and treatment tolerance. Results: Post-treatment investigations showed that H. pylori was completely eradicated in 187 patients (88.6 %), while eradication was not achieved in 24 patients (11.4 %). In the older adult group, H. pylori was successfully eradicated in 27 of 33 patients (81.8 %). Excluding a total of 9 patients who did not complete treatment due to side effects, H. pylori eradication was achieved in 184 of 202 patients (91 %). Conclusion: This combination of three antibiotics exhibits a high rate of eradication of H. pylori among adult patients, even when administered for a short period (one week). This investigation should be carried out using a larger and more diverse patient population to validate the outcomes reported in this study