Muhammad Sulaiman Zubair1 
,
Jesica Carine Poluan2,
Farida Hayati2,
Arba Pramundita Ramadani2,
Evi Sulastri1,
Ihwan 1
For correspondence:- Muhammad Zubair Email: sulaimanzubair@untad.ac.id Tel:+62-852420843654
Received: 19 October 2024 Accepted: 24 December 2024 Published: 27 January 2025
Citation: Zubair MS, Poluan JC, Hayati F, Ramadani AP, Sulastri E, I. Self-nanoemulsifying drug delivery system (SNEDDS) prepared from Begonia medicinalis and Moringa oleifera ethanol extracts. Trop J Pharm Res 2025; 24(1):1-8 doi: 10.4314/tjpr.v24i1.1
© 2025 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the activity of self-nanoemulsifying drug delivery system (SNEDDS) containing B. medicinalis and M. oleifera ethanolic extracts. Method: The SNEDDS was prepared using propylene glycol (40 %), Tween 80 (50 %), and isopropyl myristate (10 %). Transmittance percentage, particle size, polydispersity index, and zeta potential were evaluated. In vitro immunostimulant activity was measured by assessing the macrophages' phagocytic capacity and proliferation of lymphocyte cells using MTT assay. In vivo immunostimulant activity was determined by measuring the number (%) of leukocytes, neutrophils, and lymphocytes in Wistar male rats over 14 days following administration of the SNEDDS after induction with Staphylococcus aureus. Results: The SNEDDS formula of combined extract of B. medicinalis and M. oleifera demonstrated polydispersity index (0.46 ± 0.00), particle size (24.4 ± 0.1 nm), zeta potential (-37.73 ± 0.32 mV) and percentage transmittance (86.81 ± 0.16 %). In vitro and in vivo tests revealed that SNEDDS significantly increased macrophage phagocytic capacity, number of leukocytes, neutrophils and lymphocytes over 14 days of treatment (p < 0.05) following induction with S. aureus. Conclusion: Self-nanoemulsifying drug delivery system of combined ethanol extract of B. medicinalis and M. oleifera demonstrates stable physicochemical properties, and increases macrophage phagocytic activity, leukocytes, neutrophils and lymphocyte count.
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