Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Coordination compounds of M(II) biometal Ions with acid-type anti-inflammatory drugs as ligands â€“ A review

Nenad S Krstic¹ , Ruzica S Nikolic¹, Maja N Stankovic¹, Nada G Nikolic², Dragan M Doraevic¹

¹Department of Chemistry, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33; ²Medical Faculty, University of Nis, Bulevar Dr Zorana Dinaica 81, 18000 Nis, Serbia.

For correspondence:- Nenad S Krstic Email: nenad.krstic84@yahoo.com Tel:+38118514882

Received: 14 August 2014 Revised: 16 January 2015 Published: 28 February 2015

Citation: Krstic N, Nikolic R, Stankovic M, Nikolic N, Doraevic D. Coordination compounds of M(II) biometal Ions with acid-type anti-inflammatory drugs as ligands â€“ A review. Trop J Pharm Res 2015; 14(2):337-349 doi: 10.4314/tjpr.v14i2.21

© 2015 The authors.
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Abstract

The cations of biometals in biological systems easily interact with various moieties of organic and inorganic biomolecules, either as natural constituents or after introduction into the body via O-, N- and S- donor atoms. Study of the interaction between M(II) biometal–O-donor ligand (drug) is of interest for various reasons: more evenly dosing of medicine and biodistribution of medicine; monitoring of its pharmacokinetics including excretion; reduction of unwanted effects of the medicine; greater antimicrobial activity; synergistic effect of the metal and medicine; and improved anti-ulcerous, anti-tumor and anti-bacterial activity. This paper offers an overview of the literature of published research on coordination between biometals and anti-inflammatory drugs of the acid type. The metals that the subject of focus in this review are d-metals with M(II) ions, namely, copper (Cu), zinc (Zn), cobalt (Co) and manganese (Mn).Those containing molecules with carboxyl functional groups can build complexes with coordinated number of metals of 4 and 6, of various stoichiometric structures, simple or complex, and also behave as monodentate, bidentate or bridge ligands in polynuclear complexes.

Keywords: Biometals M(II), Anti-inflammatory medicine, Coordination, O-Donor ligands, Copper, Cobalt, Manganese, Zinc