Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Waqar Ahmad¹, Shakeel Ahmad Khan² , Khurram Shahzad Munawar¹, Asma Khalid³, Sadia Kawanl⁴

¹Department of Chemistry, University of Management and Technology, Lahore-54000, Pakistan; ²Department of chemistry, Hallym University, Chuncheon, Gangwon-do, 200-702, Republic of Korea; ³Institute of Chemistry, University of the Punjab, Lahore-54590; ⁴Department of Biochemistry, University of Agriculture, Faisalabad-38000, Pakistan.

For correspondence:- Shakeel Khan Email: Shakilahmad56@gmail.com

Received: 24 January 2017 Accepted: 15 April 2017 Published: 30 May 2017

Citation: Ahmad W, Khan SA, Munawar KS, Khalid A, Kawanl S. Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline. Trop J Pharm Res 2017; 16(5):1137-1146 doi: 10.4314/tjpr.v16i5.23

© 2017 The authors.
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Abstract

Purpose: To synthesize a series of mixed ligand-metal complexes and to evaluate their alkaline phosphatase inhibitory capacities, antioxidant potential and antimicrobial activities.

Method: Mixed ligand-metal complexes of Zn (II), Ni (II), Co (II), Cu (II), omeprazole and 8-hydroxyquinoline were synthesized. The ligand-metal complexes were characterized by various physicochemical techniques, including elemental analysis, magnetic susceptibility, scanning electron microscope (SEM), mass spectrometry (EI-MS), ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (¹H-NMR) and conductance studies. The new compounds were also investigated for their alkaline phosphatase (ALPs) inhibition, 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging and antimicrobial activities.

Results: Spectroscopic studies revealed the chemical composition of synthesized compounds as well as the bidentate bonding behavior of the coordinating ligands with metal ions. Conductance measurement suggested that the metal complexes were non-electrolytes. Ni(II) complex exhibited antioxidant activity (30.48 ± 0.32 x583;M) higher than those of BHT (standard) and other complexes. Stronger inhibition of ALPs by Ni (II) mixed ligand complex compared to the other complexes was evident. The synthesized compounds showed moderate to very good antimicrobial activity against bacterial strains, i.e., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Actinomyces viscosus, Staphylococcus aureus, Bacillus subtilis; as well as against the fungal strains, Candida albicans, Aspergillus flavus and Aspergillus niger.

Conclusion: All the mixed ligand complexes demonstrate higher antioxidant, ALPs-inhibitory and antimicrobial activities than their corresponding ligands. This indicates their therapeutic potential as future drug candidates for the concerned diseases

Keywords: Omeprazole, 8-Hydroxyquinoline, Mixed-ligand complexes, Alkaline phosphatase, Bidentate bonding behaviors