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Commentary | OPEN ACCESS

Effects of interacting variables on the releasevproperties of chloroquine and aminophylline suppositories

Michael A Odeniyi, Kolawole T Jaiyeoba

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria;

For correspondence:-  Kolawole Jaiyeoba   Email: jaiyeobakt@yahoo.co.uk

Published: 15 June 2004

Citation: Odeniyi MA, Jaiyeoba KT. Effects of interacting variables on the releasevproperties of chloroquine and aminophylline suppositories. Trop J Pharm Res 2004; 3(1):285-290 doi: 10.4314/tjpr.v3i1.4

© 2004 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose:  The  individual  and  interaction  effects  of  formulation  variables  on  the  release  of suppositories  were  investigated  using  a  2 3 factorial  experimental  design.  The  variables studied were nature of base (B), type of drug (D), and presence of surfactant (S).
Method:  Suppositories  were  formulated  with  theobroma  oil  and  Witepsol  H15  as  bases  at ‘low’  and  ‘high’  levels  respectively.  Chloroquine  and  aminophylline,  both  water-soluble  drugs, were incorporated as active constituents at ‘low’ and ‘high’ levels respectively while Tween 80 was  incorporated  as  surfactant  in  some  of  the  formulations.  Disintegration  time  and  time taken for 50% of the drug to dissolve were used as assessment parameters.
Results:  The  inclusion  of  surfactant  in  the  suppository  formulation      proved  to  be  the  most significant  variable  in  the  formulation.  The  ranking  for  the  individual  coefficient  values  for  the formulations  was  S>>B>D  for  disintegration  time  DT  and  S>>>D>B  for  the  dissolution parameter  t50.  While  the  ranking  for  the  interaction  effects  was  B-D>B-S>S-D  on  DT  and  on t50 S-D>B-S>B-D.
Conclusion:  The  results  suggest  that  in  formulating  water-soluble  drugs  such  as  chloroquine and aminophylline  as suppositories in a hydrophobic base, the presence of a surfactant is the most influential variable.

Keywords: Suppositories, chloroquine, aminophylline, surfactant, interacting variables.

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Thompson Reuters (ISI): 0.6 (2023)
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