Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-ulcer and anti-inflammatory effects of hydro-alcohol extract of Aloe buettneri A. Berger (lilliaceae)

K Metowogo, A Agbonon, F Eklu-Gadegbeku, A K Aklikokou, M Gbeassor

Centre de Formation et de Recherche sur les Plantes MÃ©dicinales (CERFOPLAM), Laboratoire de Pharmacologie-Physiologie, FacultÃ© des Sciences. UniversitÃ© de LomÃ©-Togo.;

For correspondence:- M Gbeassor Email: gbeassor@tg.refer.org Tel:(228)2250877

Published: 12 March 2008

Citation: Metowogo K, Agbonon A, Eklu-Gadegbeku F, Aklikokou AK, Gbeassor M. Anti-ulcer and anti-inflammatory effects of hydro-alcohol extract of Aloe buettneri A. Berger (lilliaceae). Trop J Pharm Res 2008; 7(1):907-912 doi: 10.4314/tjpr.v7i1.6

© 2008 The authors.
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Abstract

Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema, analgesic, antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves.

Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1%, tail flick method is used to study analgesic property, hyperthermia was induced by subcutaneous injection of 15% of a brewers' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or HCl/ethanol mixture.

Results: The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It inhibited, in a dose- dependent manner, the oedema induced by 0.1 ml of formaldehyde 1%. Scores of 73.70% and 83.63% were obtned when the doses of extract administered were 100 and 500 mg/kg, respectively. The tail flick analgesic index showed an increase of 36.56% when the dose was 500 mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000 mg/kg of the extract inhibited 63.77% of the gastric lesion induced by acid-water-ethanol mixture while daily administration of the same dose accelerated the cicatrisation of gastric ulcer induced by 95% ethanol.

Conclusion: The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger (Lilliaceae) has anti-inflammatory, anti-ulcer and wound healing properties

Keywords: Aloe buettneri, oedema, analgesic, hyperthermia, ulcer.