Adebola Onanuga1,2 
,
Josiah A Onaolapo1
For correspondence:- Adebola Onanuga Email: adebolaonanuga@yahoo.co.uk
Published: 12 March 2008
Citation: Onanuga A, Onaolapo JA. Antimicrobial Susceptibility of community-associated Staphylococcus aureus isolates from healthy women in Zaria, Nigeria.. Trop J Pharm Res 2008; 7(1):929-934 doi: 10.4314/tjpr.v7i1.9
© 2008 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: An investigation of the antimicrobial susceptibility patterns of Staphylococcus aureus isolated from healthy women to ten commonly used antimicrobial drugs was carried out as a basis for a guide for empirical antimicrobial treatment using urine samples.
Method: The samples collected from healthy women volunteers in Zaria were cultured and screened for S. aureus using standard microbiological procedures. The antimicrobial susceptibility of the isolates was investigated using disc diffusion technique.
Result: A total of 54(36%) S. aureus isolates were isolated from 150 urine samples collected. Of the 54 isolates, 16 (29.6%), 15 (27.8%) and 23 (42.6%) were from married but not pregnant, pregnant and single women respectively. The isolates were highly susceptible to ciprofloxacin, gentamicin, ofloxacin, sparfloxacin and pefloxacin in both groups (married and single). The differences observed in all the antimicrobial drugs tested for both groups were not statistically significant (p>0.05). A total of 34 (63%) of the isolates showed multi-drug resistance and only 6 (11%) were susceptible to all the antimicrobial drugs tested.
Conclusion: This observation calls for measures to reduce the reservoir of antimicrobial resistant organisms in healthy populations.
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