Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Development and characterization of orodispersible tablets of famotidine containing a subliming agent

S Furtado , R Deveswaran, S Bharath, B V Basavaraj, S Abraham, V Madhavan

M.S Ramaiah College of Pharmacy, M.S.R. Nagar, M.S.R.I.T Post, Bangalore-560054.India;

For correspondence:- S Furtado Email: sharoncaroline@rediffmail.com Tel:+918023608942

Received: 10 April 2008 Accepted: 25 August 2008 Published: 16 December 2008

Citation: Furtado S, Deveswaran R, Bharath S, Basavaraj BV, Abraham S, Madhavan V. Development and characterization of orodispersible tablets of famotidine containing a subliming agent. Trop J Pharm Res 2008; 7(4):1185-1189 doi: 10.4314/tjpr.v7i4.12

© 2008 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets.

Method: Orodispersible tablets of famotidine were prepared using camphor as subliming agent and sodium starch glycollate together with crosscarmellose sodium as superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution.

Result: All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals.

Conclusion: This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Keywords: Mouth dissolving tablet, Famotidine, Subliming agent, Super disintegrant, Camphor.