Research Article

Inhibition of Nitric Oxide and Prostaglandin E₂ Expression by Methanol Extract of Polyopes affinis in Lipopolysaccharide-stimulated BV2 Microglial Cells through Suppression of Akt-dependent NF-κB Activity and MAPK Pathway

Rajapaksha Gedara Prasad Tharanga Jayasooriya¹, Yeon-Jeong Jang¹, Chang-Hee Kang¹, Matharage Gayani Dilshara¹, Dong-Oh Moon², Taek-Jeong Nam³, Yung Hyun Choi^4* and Gi-Young Kim^1*

¹Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, ²Department of Biology Education, College of Education, Daegu University, Gyeongsan, Gyeongbuk 712-714, ³Department of Food Science and Biotechnology, Pukyong National University, Busan 608-737, ⁴Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-051, Republic of Korea

*For correspondence: E-mail: yhchoi@deu.ac.kr or  immunkim@jejunu.ac.kr  Tel: +82 64 754 3427; Fax: +82 64 756 3493

Received: 24 May 2012                                                                          Revised accepted: 28 October 2012

Tropical Journal of Pharmaceutical Research, February 2013; 12(1): 63-70