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Research Article
Antibacterial activity of the aqueous extract of Thonningia sanguinea against Extended-Spectrum-b-Lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae strains
JD N’guessan1, MR Dinzedi1,2, N Guessennd2, A Coulibaly1, M Dosso2,3, AJ Djaman3, F Guede-Guina1
1Laboratoire de Pharmcodynamie Biochimique, 22 BP 582 Abidjan 22, Côte d’Ivoire
2Département de Bactériologie & Virologie- Institut Pasteur de Côte d’Ivoire, 01 BP 490 Abidjan 01, Côte d’Ivoire
3Laboratoire de Biochimie - Institut Pasteur de Côte d’Ivoire, 01 BP 490 Abidjan, Côte d’Ivoire
Tropical Journal of Pharmaceutical Research 2007; 6(3): 779-783
ISSN: 1596-599
Abstract
Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae.
Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains.
Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains.
Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E .coli, K. pneumoniae.
Key words: Antimicrobial activity, Thonningia sanguinea, ESBL producing strains; E. coli.
*Correspondence: Tel : (00225) 05-78-57-89 E-mail: nguess100jd@yahoo.fr