Purpose:
To compare the
mucoadhesive performance of grewia polysaccharide gum
with those of guar gum, carboxymethylcellulose,
hydroxypropyl methylcellulose and carbopol 971P.
Methods:
Grewia
polysaccharide gum compacts or gels as well as those of
guar gum, carboxymethylcellulose, hydroxypropyl
methylcellulose or carbopol 971P were prepared.
Texturometric and tensile analysis of the polymer gels
and compacts were carried out using a
software-controlled penetrometre, TA.XTPlus texture
analyzer. The polymer gels were evaluated for hardness,
stickiness, work of cohesion and work of adhesion.
Furthermore, the detachment force of the polymer
compacts from a mucin substrate was evaluated.
Results:
The work of
adhesion of guar gels was significantly greater than
that of grewia gels (p < 0.001) but the latter showed a
significantly greater work of adhesion than
carboxymethylcellulose gels (p < 0.05) and hydroxypropyl
methylcellulose gels (p < 0.001). However, the work of
cohesion for grewia/mucin gel mixture was significantly
greater (p < 0.001) than those of carboxymethylcellulose/mucin,
hydroxypropyl methylcellulose/mucin and carbopol 971P/mucin
gel blends. The difference between the mucoadhesive
performance of grewia compacts and those of
hydroxypropyl methylcellulose and carbopol 971P compacts
was insignificant (p > 0.05).
Conclusion:
Grewia
polysaccharide gum demonstrated good mucoadhesive
properties, comparable to those of carbopol 971P,
carboxymethylcellulose, guar gum and hydroxypropyl
methylcellulose, and therefore, should be suitable for
the formulation of retentive drug delivery devices.
Keywords:
Grewia polysaccharide gum, Texture analyzer,
Mucoadhesive performance, Work of cohesion/adhesion.
