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Original Research Article
Prevalence of Hepatitis B
and C Virus in Euthyroid Patients
X Xu1, KM Sajid2,
X Zhai3, W Yao4, S Mir5,
R Mahmood4, AK Khan5, MHHB Asad6,
K Farzana7, G Murtaza6, T Li3*
1Zhengzhou Traditional Chinese
Medicine Hospital, Zhengzhou, China, 2Multan
Institute of Nuclear Medicines and Radiology, Nishtar
Hospital, Multan, Pakistan, 3Beijing
University of Chinese Medicine, Beijing, 4China
Development Bank, Beijing, China, 5Department
of Chemistry, 6Department of Pharmacy,
COMSATS Institute of Information Technology 22060,
Abbottabad, 7Department of Pharmaceutical
Sciences, Riphah International University, Lahore,
Pakistan
*For correspondence:
Email:
gmdogar356@gmail.com; Tel:
0092-3142082826; Fax: 0092-992383441
Received: 26 May 2014
Revised accepted: 13
September 2014
Tropical
Journal of Pharmaceutical Research, October 2014;
13(10): 1 703-1706
http://dx.doi.org/10.4314/tjpr.v13i10.19
Abstract
Purpose: To determine the prevalence
of hepatic infections, viz, hepatitis B (HBV) virus and
hepatitis C virus (HCV), in the euthyroid population of
Southern Punjab Province of Pakistan.
Methods: A total of 120 euthyroid
patients (36 male and 84 female) with a mean age of 30.7
± 0.09 years) were included in this study. HBV and HCV,
as well as the thyroid hormones, namely,
triiodothyronine (T3), thyroxine (T4), and
thyroid-stimulating hormone (TSH) were detected in the
serum of the subjects using commercial kits.
Results: Out of 120 subjects 4 (3.3
%) were positive for HBsAg (hepatitis B surface antigen)
and 18 (15 %) for anti-HCV. HCV infection was
approximately 4 times higher than HBV infection (p =
0.00028). Prevalence of HBsAg in males (8 %) was
significantly higher than in females (1.2 %, p =
0.006345) whereas prevalence of HCV in males (16.7 %)
was not significantly different from that in females
(14.2 %, p = 0.521303). HCV (16.7 %) was significantly
higher than HBV infection (8.33 %, p = 0.0102) in male
sufferers. Similarly, among females patients, the
incidence of HCV (14.2 %) was significantly higher (p =
0.000011) than HBV infection (1.2 %).
Conclusion: The prevalence of HCV is
higher than that of HBV in the studied population;
furthermore, this prevalence of HCV is higher than
values reported in other studies. The high level of HCV
infection in the studied population is of concern,
indicating the need for preventive measures to be put in
place.
Keywords: Hepatitis B, Hepatitis C,
Prevalence, Euthyroid |
