Tropical Journal of Pharmaceutical Research

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Research Article

Phytochemical Screening and In-vivo Antipyretic Activity of the Methanol Leaf-Extract of Bombax Malabaricum DC (Bombacaceae)

Emdad Hossain¹, Subhash C Mandal² and JK Gupta^2*

¹Pharmacy College, Azamgarh 276128, Uttar Pradesh, ²Department of Pharmaceutical Technology, Jadavpur University, Kolkata700 032, India

*For correspondence: E-mail: jkgjupt@yahoo.co.in OR hossainemdad@yahoo.com Tel: +91-33-24053055;

Fax: +91-5462-243134

Received: 2 July 2010 Revised accepted: 12 December 2011

Tropical Journal of Pharmaceutical Research, February 2011; 10(1): 55-60

Abstract

Purpose: To investigate the antipyretic activity of the methanol extract of Bombax malabaricum leaves (MEBM) in rats.

Methods: Baker’s yeast was used to induce fever in Wistar rats which were divided into four groups. The animal groups were thereafter administered MEBM (200 mg/kg), MEBM (400 mg/kg), paracetamol (reference standard, 150 mg/kg) and 1 % Tween 80 (control), respectively. The body temperature of the rats was measured rectally over a period of 8 h. MEBM was also phytochemically screened for alkaloids, steroids, carbohydrates, tannins, fixed oils, proteins, triterpenoids, deoxy-sugar, flavonoid, cyanogenetic and coumarin glycosides.

Results: MEBM (200 mg/kg and 400 mg/kg) significantly reduced yeast-induced pyrexia (p < 0.05, p < 0.01, respectively). Phytochemical tests showed the presence of steroids, carbohydrates, tannins, triterpenoids, deoxy-sugars, flavonoids and coumarin glycosides.

Conclusion: The methanol extract of Bombax malabaricum leaves possesses significant antipyretic activity.

Keywords: Antipyretic activity, Baker’s yeast, Bombax malabaricum, Phytochemical screening