Tropical Journal of Pharmaceutical Research

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Research Article

Glipizide Pharmacokinetics in Healthy and Diabetic Volunteers

Muhammad Atif^1*, Mahmood Ahmad², M Qamar-uz-zaman², Muhammad Asif², Syed Azhar Syed Sulaiman¹, Asrul Akmal Shafie³, I Masood¹, Usman Minhas² and Najam Us-saqib⁴

¹Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, 11800, Penang, Malaysia, ²Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab, Pakistan, ³Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, 11800, Penang, Malaysia, ⁴Ministry of Health, Government of Pakistan.

*For correspondence: E-mail: pharmacist_atif@yahoo.com Tel: +60-4-6566962; Cell: +60-14-7572474

Received: 13 September 2010 Revised accepted: 15 February 2011

Tropical Journal of Pharmaceutical Research, April 2011; 10(2): 147-152

Abstract

Purpose: Disease state may contribute to alteration in drug pharmacokinetics. The purpose of this study was to determine the effect of non-insulin dependent diabetes mellitus (NIDDM) on the pharmacokinetics of glipizide.

Methods: An open, single-dose, parallel design was applied to the study. Glipizide tablet (5 mg) was administered to healthy and diabetic human volunteers after over-night fast. Blood samples were collected, centrifuged and the plasma assayed using a sensitive and validated reverse phase high performance liquid chromatography (RP-HPLC) method. Various pharmacokinetic parameters were computed from the data obtained.

Results: The AUC_0-∞ values for healthy and diabetic volunteers was 1878 ± 195 and 1723 ± 138 ng.h/ml, respectively; these values were not significantly different (p > 0.05). The t_1/2for healthy volunteers was 3.04 ± 0.27 h while that for diabetic subjects was 2.98 ± 0.16 h. Clearance for healthy and diabetic volunteers was 0.59±0.06 and 0.64±0.05 ml/min/kg, respectively. These and other pharmacokinetic parameters assessed were not significantly different between healthy and diabetic volunteers (p > 0.05).

Conclusion: Although glipizide showed slightly more rapid clearance from the body of diabetic volunteers than from healthy volunteers, this difference, like those for other pharmacokinetic parameters, was not significant (p > 0.05).

Keywords: Glipizide, Bioavailability, Pharmacokinetics, Plasma, Reversed Phase-High performance liquid chromatography.