Structural Analysis of Ciprofloxacin-Carbopol Polymeric
Composites by X-Ray Diffraction and Fourier Transform
Infra-Red Spectroscopy
S Sahoo1*, CK
Chakraborti1, S Naik1, SC Mishra2
and UN Nanda3
1Kanak
Manjari Institute of Pharmaceutical Sciences, Rourkela
769015, 2Metallurgical and Materials
Engineering. Dept, National Institute of Technology,
Rourkela 769008, 3Seemanta Institute of
Pharmaceutical Sciences, Jharpokharia, Mayurbhanj
757086, India
For correspondence:
E-mail:
subha77t@yahoo.co.in Tel:
+91-9861376820; Fax: +91-661-2480752
Received: 3 November
2010
Revised accepted: 12 April 2011
Tropical
Journal of Pharmaceutical Research, June 2011;
10(3):
273-280
doi:
10.4314/tjpr.v10i3.14
Abstract
Purpose:
To evaluate
physicochemical changes in ciprofloxacin following
incorporation in Carbopol polymeric composites.
Methods:
The ciprofloxacin
and Carbopol were mixed in water in a drug:polymer ratio
of 1:5 (w/w) and homogenized to produce uniform
composites. X-ray powder diffraction analysis of the
pure ciprofloxacin and the Carbopol polymeric composites
of the drug were obtained using a powder diffractometer.
Spectra for the materials were also generated by Fourier
transform infrared (FTIR) spectroscope interfaced with
an infrared (IR) microscope operated in reflectance
mode.
Results:
Based on the Hanawalt system, three prominent x-ray
diffractogram (XRD) peaks of the pure ciprofloxacin and
the drug in the polymeric composites exhibited d-spacing
at similar 2θ values, but the relative intensity of
these peaks was higher in the polymeric composites. FTIR
analysis indicates that there were intermolecular
hydrogen bonding and esterification between the drug and
polymer in the polymeric composites.
Conclusion:
The changes
that occurred in ciprofloxacin indicate increase in
stability, decrease in solubility and delayed release of
the drug from polymeric composites which could
facilitate the formulation of a sustained release form
of the drug.
Keywords:
Ciprofloxacin,
X-ray diffraction, Fourier transform infrared, Carbopol,
Polymeric composites
