Tropical Journal of Pharmaceutical Research

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Review Article

Antiprotozoal Activity of α,β-Unsaturated δ-Lactones: Promising Compounds for the Development of New Therapeutic Alternatives

Cardona G Wilson* and Saez V Jairo

Instituto de Química, Química de Plantas Colombianas, Universidad de Antioquia, A.A 1226, Medellín, Colombia

For correspondence: E-mail: rlamboni@tg.refer.org Tél: 00228 903 29 90

Received: 24 March 2011 Revised accepted: 22 August 2011

Tropical Journal of Pharmaceutical Research, Oct 2011; 10(5): 671-680

http://dx.doi.org/10.4314/tjpr.v10i5.17

Abstract

The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δ-lactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review.

Keywords: Lactones, Pyrones, Antiparasitic, Antiprotozoal, Leishmania, Malaria, Chagas, Plasmodium falciparum, Tripanosoma cruzi.