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Research Article
Effect of Dietary Intake of Fermented Seeds of Parkia
biglobosa (Jacq) Benth (African Locust Bean) on
Hypertension in Bogou and
Goumou-kope Areas of
Togo
K Ognatan1, K. Adi1,3, C
Lamboni1*, J-M Damorou2,
KA Aklikokou3, M Gbeassor3 and J-C
Guilland4
1Laboratoire
de Biochimie/Nutrition, Université de Lomé, Faculté des
Sciences, 2Service de Cardiologie du Centre
Hospitalier Universitaire, Faculté de Médecine, 3Laboratoire
de Physiologie-Pharmacologie, Faculté des Sciences,
Université de Lomé, BP : 1515 Lome, Togo, 4Practicien
hospitalier, Unité Neuromédiateurs et Vitamines,
Laboratoire de Physiologie de la Faculté de Médecine,
Université de Bourgogne, BP 87900 Bd Jeanne-d’Arc,
21033 Dijon-Cedex, France.
For
correspondence:
E-mail:
pvdesai@unigoa.ac.in
pv26in@yahoo.co.in
Tel:
91-08326519363; Fax: 91-08322456133
Received: 9
September 2010 Revised
accepted: 25
August 2011
Tropical
Journal of Pharmaceutical Research, Oct 2011;
10(5): 603-609
http://dx.doi.org/10.4314/tjpr.v10i5.9
Abstract
Purpose:
To identify the possible effect of the consumption of
fermented seeds of Parkia biglobosa (Jack) Benth,
Mimosaceae (African locust bean) by humans on the
prevention of hypertension.
Methods:
Two types of populations
in Togo were identified and compared: one type was in a
region (Bogou) where the condiment (Parkia biglobosa
seeds) is highly consumed and the other people do not
eat it at all (Goumou-kope). Anthropometrical, clinical
and biochemical analyses were investigated in both
target groups.
Results:
Significantly decreased
blood pressure and heart beat were detected in the group
of people living in Bogou’s region when compared to the
non-consumption group of Goumou-kope (p < 0.001).
Magnesium level was significantly increased in the Bogou
group compared to that in the second group (p < 0.0001).
Lower levels of low density lipoprotein-cholesterol (91±
36 vs. 110 ± 44 mg/dL, p = 0.01), triglycerides (111 ± 6
vs. 129 ± 6 mg/dL, p = 0.028), and higher levels of high
density lipoprotein-cholesterol (63 ± 2 vs. 48 ± 3 mg/dL,
p < 0.001) were observed in subjects who regularly
consummed P. biglobosa fermented seeds. Furthermore,
plasma glucose concentration was significantly lower in
Bogou group than in Goumou-kope (68 ± 16 vs. 76 ± 15 mg/dL
(p < 0.001).
Conclusion:
The results
of the present study demonstrate that fermented seeds of
Parkia biglobosa
exert
an anti-hypertension effect.
Keywords:
Blood minerals, Plasma lipids, Antihypertensive,
Parkia biglobosa seeds |
