Effect of Elaeagnus Conferta Roxb (Elaeagnaceae)
Dry Fruit on the Activities of Hepatic Alcohol
Dehydrogenase and Aldehyde Dehydrogenase in Mice
Chongming Wu1, Rongji
Dai1,2, Jingmiao Bai1, Yan Chen1,2,
Yuhong Yu1,2, Weiwei Meng1,2* and
Yulin Deng1,2
1School
of Life Science, Beijing Institute of Technology,
Beijing 100081, 2GY Pharmaceutical R&D,
Beijing 100081, PR China
For correspondence:
E-mail:
mww919@bit.edu.cn
Tel: +86-10-68949331; Fax: +86-10-68467208
Received: 18 March
2011 Revised
accepted: 20 October, 2011
Tropical
Journal of Pharmaceutical Research, December 2011;
10(6): 761-766
http://dx.doi.org/10.4314/tjpr.v10i6.9
Abstract
Purposes:
To determine the effect of Elaeagnus conferta
Roxb dry fruit powder (ECR) on blood alcohol clearance
and on the activities of hepatic alcohol dehydrogenase (ADH)
and aldehyde dehydrogenase (ALDH).
Methods:
In a randomized controlled study, acute alcohol
intoxication was induced in mice with Hongxing liquor
containing 65 % v/v ethanol orally. The effect of ECR on
blood alcohol clearance and on the activities of hepatic
alcohol dehydrogenase and aldehyde dehydrogenase in the
mice was then investigated.
Results:
A 30-min pretreatment with ECR at 400 and 800 mg/kg led
to a faster clearance of blood
alcohol after the alcohol ingestion. The
concentration of blood alcohol at 4 h after alcohol
ingestion decreased by 21.2 % in mice pretreated with
800 mg/kg ECR. The activities of hepatic alcohol
dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)
were enhanced by ECR.
Conclusion:
These results suggest that pretreatment with ECR might
stimulate the clearance of blood alcohol by increasing
the activities of hepatic alcohol dehydrogenase and
aldehyde dehydrogenase.
Keywords:
Elaeagnus conferta Roxb, blood alcohol clearance,
alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH).
