|
|
Research Article
Anti-Stress and
Anti-Amnesic Effects of Coriandrum sativum Linn (Umbelliferae)
Extract – an Experimental Study in Rats
Sushruta Koppula* and Dong Kug Choi
College of Biomedical
and Health Sciences, Department of Biotechnology, Konkuk
University, Chungju, Republic of Korea.
*For correspondence:
Email:
koppula@kku.ac.kr
Tel: +82-43-840-3609 Fax:
+82-43852-3616
Received: 19 April
2011 Revised
accepted: 22 December 2011
Tropical
Journal of Pharmaceutical Research, February 2012;
11(1):
36-42
http://dx.doi.org/10.4314/tjpr.v11i1.5
Abstract
Purpose:
Coriandrum sativum Linn. (Umbelliferae, C.
sativum) is cultivated throughout the world for its use
as spice and as a folk medicine. This study deals with
the anti-stress and anti-amnestic properties of C.
sativum extract in rats.
Methods:
Urinary levels of vanillylmandelic acid (VMA) and
ascorbic acid were used to evaluate anti-stress activity
in rats, while conditioned avoidance response test in
normal and scopolamine-induced amnesic rats was used to
evaluate anti-amnesic effects. C. sativum extract was
also evaluated for its antioxidant activities by
inhibition of lipid peroxidation in brain and liver
homogenates of the rats.
Results:
Daily administration of C. sativum extract (100, 200 and
300 mg/kg body weight) 1 h prior to induction of stress
significantly decreased the stress-induced urinary
levels of VMA from 382.79 ± 10.70 to 350.66 ± 15.15,
291.21 ± 16.53 and 248.86 ± 13.56 µg/kg/24 h and
increased the ascorbic acid excretion levels from 66.73
± 9.25 to 69.99 ± 7.37, 105.28 ± 13.74 and 135.32 ±
12.54 µg/kg/24 h at 100, 200 and 300 mg/kg,
respectively, in a dose-dependent fashion without
affecting the normal levels in control groups. The
amnesic deficits (acquisition, retention and recovery)
induced by scopolamine (1mg/kg, i.p.) in rats was
reversed by C. sativum dose dependently. The extract
also inhibited lipid peroxidation in both rat liver and
brain to a greater extent than the standard antioxidant,
ascorbic acid.
Conclusion:
C. sativum may be useful remedy in the management of
stress and stress related disorders
on account of its multiple actions such as
anti-stress, anti-amnestic and antioxidant effects.
Keywords:
C. sativum, Stress, Lipid peroxidation, Vanillylmandelic
acid, Memory. |
