http://dx.doi.org/10.4314/tjpr.v11i3.5
Abstract
Purpose: To evaluate a weakly cationic
exchange poly(methacrylic acid-co-divinylbenzene) resin
(PMD) as a new filler-binder for direct compression
tablets.
Methods: Powder properties of PMD and MCC
were characterized. Tablets made from PMD and MCC with
and without propranolol hydrochloride were evaluated for
diameter, thickness, friability, assay, disintegration,
dissolution and compression behavior.
Results: Tablets made from PMD (thickness:
3.54 - 4.46 mm) were thicker than those of MCC (2.93 -
3.33 mm). At compression pressures ≥ 309 MPa, the
crushing strength of PMD tablets was so high that it
exceeded the capacity of the tester (500 N). PMD tablets
rapidly disintegrated (0.43 - 9.56 min), but MCC tablets
did not disintegrate within 60 min. The crushing
strength of PMD tablets containing 10 and 100 mg
propranolol hydrochloride was 406.1 and 177.9 N,
respectively, which were lower than that of tablets
without the drug. Tablets made from PMD also exhibited
faster drug dissolution. The slopes of the linear
portions of Heckel plots for PMD and MCC were comparable
(5.02×10-3 and 5.12×10-3 MPa-1),
respectively.
Conclusion: PMD has good compressibility at high compression
pressures, which should make it a suitable filler-binder
for direct compression tablets.
Keywords:
Poly(methacrylic acid-co-divinylbenzene),
Microcrystalline cellulose, Filler-binder, Direct
compression tablet, Heckel plots.
