http://dx.doi.org/10.4314/tjpr.v11i5.12
Abstract
Purpose: DAS-77 is a phytomedicine that
contains the dried bark of Mangifera indica and root of
Carica papaya. This study investigated the antiulcer
effects of DAS-77 in rats.
Methods: DAS-77 was administered orally twice
daily for five consecutive days at doses of 50 - 400
mg/kg. Ulcer was induced in rats with ethanol,
indomethacin, pylorus ligation (PL) and cold restraint
stress (CRS). Ulcer scores were recorded based on
examination of excised stomachs. Estimations of gastric
content volume, pH and titratable acidity in the PL
model and determination of the levels of antioxidants
and malondialdehyde (MDA) in gastric tissues in the CRS
model were also done.
Results: In all the models, DAS-77
produced significant dose-dependent reductions in ulcer
score. Peak effects were produced at the dose of 400
mg/kg with ulcer inhibition values of 98.57, 76.23,
99.28 and 96.70 % compared to 100.00, 93.79, 98.92 and
96.79 % for misoprostol/cimetidine, respectively, for
the ethanol, indomethacin, PL and CRS models. In the PL
model, DAS-77 caused a significant increase in pH of
gastric content but a reduction in volume and titratable
acidity. At doses of 50 and 100 mg/kg in the CRS model,
DAS-77 significantly increased the level of reduced
glutathione (GSH) and diminished MDA.
Conclusion: The results obtained in this study
suggest that DAS-77 possesses gastroprotective activity
possibly due to reduced gastric secretion and acidity,
and antioxidant activity.
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