Tropical Journal of Pharmaceutical Research

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Review Article

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Evren Algin Yapar^1* and Özge İnal²

¹Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, Söğütözü Mah. 2176. Sok. No:5 Kat:6, 06520 Çankaya-Ankara, ²Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan- Ankara, Turkey

*For correspondence: Email: algin@pharmacy.ankara.edu.tr or evrenalgin@yahoo.com Tel: +90-532-382 56 86

Received: 30 January 2012 Revised accepted: 6 August 2012

Tropical Journal of Pharmaceutical Research, October 2012; 11(5): 855-866

http://dx.doi.org/10.4314/tjpr.v11i5.20

Abstract

Amphiphilic poly(ethylene oxide)–poly(propylene oxide) (PEO–PPO)-based copolymers are thermoresponsive materials having aggregation properties in aqueous medium. As hydrosolubilizers of poorly water-soluble drugs and improved stability of sensitive agents, these materials have been investigated for improvement in solubility, stability, release and bioavailability of drugs. The goal of the present review is to summarize the properties of PEO–PPO based copolymers and highlight the works that have been carried out on these materials for transdermal drug delivery.

Keywords: PEO–PPO based copolymer, Poloxamer, Hydrogel, Transdermal, Drug delivery.