http://dx.doi.org/10.4314/tjpr.v11i5.3
Abstract
Purpose: To prepare and evaluate floating
microspheres of curcumin for prolonged gastric residence
time and increased drug bioavailability.
Methods: Floating microsphere were prepared
by emulsion solvent diffusion method, using
hydroxylpropyl methylcellulose (HPMC), ethyl cellulose
(EC), Eudragit S 100 polymer in varying ratios.
Ethanol/dichloromethane blend was used as solvent in a
ratio of 1:1. The floating microspheres were evaluated
for flow properties, particle size, incorporation
efficiency, as well as in-vitro floatability and drug
release. The shape and surface morphology of the
microspheres were characterised by optical and scanning
electron microscopy.
Result:
The floating microspheres showed particle size,
buoyancy, drug entrapment efficiency and yield in the
ranges of 251 - 387 µm, 74.6 - 90.6 %, and 72.6 - 83.5
%, and 45.5 - 82.0 %, respectively. Maximum drug release
after 20 h was 47.1, 55.7, 69.4 and 81.3 % for
formulations F1, F2, F3 and F4, respectively. Scanning
electron micrographs indicate pores both on the surface
and interior of the microspheres.
Conclusion: The developed curcumin microsphere system is a
promising floating drug delivery system for oral
sustained administration of curcumin.
Keywords: Gastro-retentive, Sustained release,
Curcumin, Floating microspheres; Ethyl cellulose,
Hydroxylpropyl methylcellulose, Eudragit
