http://dx.doi.org/10.4314/tjpr.v11i5.7
Abstract
Purpose:
To
assess the effects of potassium adaptation on some
biochemical parameters in diabetic rats treated with
metformin.
Methods: Diabetes was induced via
intraperitoneal administration of streptozotocin in
potassium-adapted and non-adapted rats and, then
metformin (350 mg/kg) was administered orally. The
following parameters were then evaluated 24 h after drug
administration: urine volume, plasma glucose, plasma and
urine creatinine and creatinine clearance. Lipid
profiles and plasma and urine urea were also determined.
Results:
The blood glucose of the potassium-adapted diabetic
group was not significantly reduced on treatment with
metformin, compared to non-adapted diabetic rats which
were significantly reduced (p < 0.05) on metformin
treatment. The potassium-adapted group treated with
metformin had significantly higher creatinine clearance
(p < 0.05) than the non adapted group. Urine volumes for
both the diabetic and the potassium-adapted diabetic
rats were significantly lower (p < 0.05) on treatment
with metformin.
Conclusion: The results indicate that potassium adaptation
induces resistance to treatment with metformin and
increases creatinine clearance in diabetic rats.
Keywords: Metformin, hypoglycemia, potassium,
adapted rats, non-adapted rats.
