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Research Article


Anti-inflammatory and Analgesic Activities of Amorphophallus bulbifer (Roxb) Kunth Whole Plant

Srinivas K Reddy1*, Sanjeeva A Kumar1, Vinay D Kumar1 and S Ganapaty2

1Department of Pharmacognosy and Phytochemistry, Vaagdevi College of Pharmacy, Hanamkonda-506001, Andhra Pradesh, 2Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam- 530003, Andhra Pradesh, India

*For correspondence: Email: seenukaruka@yahoo.com  Tel: +91-9949810812

Received:  29 October 2011                                               Revised accepted: 17 October 2012

Tropical Journal of Pharmaceutical Research, December 2012; 11(6): 971-976

http://dx.doi.org/10.4314/tjpr.v11i6.14  

Abstract

 

Purpose: To investigate the anti-inflammatory and analgesic activities of the  Amorphophallus Bulbifer in Wistar rats and mice.

Methods: The anti-inflammatory activity of the hydroalcohol extract of A. bulbifer whole plant at dose levels of 100 and 200 mg/kg p.o. in rats was determined with a plethysmograph paw volume difference of the animals pre- and post-treatment. Ibuprofen (10 mg/kg) was employed as reference standard. Analgesic activity was evaluated using tail flick and tail immersion techniques, by measuring the reaction time of the animals treated with either standard or extract. Pentazocin (30 mg/kg) was used as reference standard.

Results: The extract showed significant anti-inflammatory and analgesic activities at the two test dose levels at the 4th hour (p < 0.001). The extract exhibited anti inflammatory activity of 56.5 (p < 0.001) and 57.1 % (p < 0.001) inhibition compared to the control group in the carrageenan and histamine-induced inflammation model at a dose of 200 mg/kg. For analgesic activity, the extract showed reaction times of 7.33 (p < 0.001) and 7.83 (p < 0.001) min in the tail flick and tail immersion models, respectively, at a dose of 200 mg/kg while the normal and reference groups exhibited reaction times of 2.16, 2.66 and 8.16 (p < 0.001) and 8.5 (p < 0.001) in the tail flick and tail immersion methods, respectively.  

Conclusion:  Based on the findings, it can be concluded that Amorphophallus bulbifer possesses anti-inflammatory and analgesic properties and this lends some support for its use in traditional medical practice.

 

Keywords: Amorphophallus bulbifer, Anti-inflammatory activity, Analgesic activity

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