Indexed by Science Citation Index (SciSearch), International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index Copernicus, EBSCO, African Index Medicus, JournalSeek, Journal Citation Reports/Science Edition, Directory of Open Access Journals (DOAJ), African Journal Online, Bioline International, Open-J-Gate

ISSN: 1596-5996 (print); 1596-9827 (electronic)-


Home | Back Issues | Current Issue | Review manuscript | Submit manuscript

 
 

This Article

 

Abstract

 

Full-Text (PDF)

 

Table of contents

 

Comments

 

Letters

 

Comments to Editor

 

e-mail Alert

 

Sign Up

 

Review Article


 

Pharmaceutical Approaches and Advancements in Male Contraception

Evren Algın Yapar1* and Özge İnal2

1Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency Söğütözü Mah. 2176. Sok. No:5 Kat:6, 06520 Çankaya-Ankara, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan- Ankara, Turkey  #

*For correspondence: Email: algin@pharmacy.ankara.edu.tr or evrenalgin@yahoo.com  Tel: +90-532-382 56 86

Received:  7 March 2012                                                  Revised accepted: 31 October 2012

Tropical Journal of Pharmaceutical Research, December 2012; 11(6): 1013-1021

http://dx.doi.org/10.4314/tjpr.v11i6.19  

Abstract

Currently available contraceptive methods offer a variety of options for women, but only very few for men which include surgical methods, condom and hormonal methods. Non-surgical and non-hormonal methods are under investigation. Among these, hormonal contraceptive approaches, including injections, oral and transdermal delivery systems of testosterone, have attracted the attention of investigators. Also non-hormonal approaches based on chemicals extracted from different plants such as cotton seed plant, Neem tree, Trypterigium wilfordii and Momordica Charantia seed, are known to have effect on male fertility. Additionally, alkylated imino sugars, Ca++ channel blockers, indenopyridines, indazole-3-carboxylic acid analogues, reversible inhibition of sperm under guidance (RISUG) which involves injection of stericmaleic anhydride with dimethyl sulfoxide, spermicide–microbicide (including gel formulations) and vaccine approaches are intended to interfere in a certain fertilization step. Information obtained from multi-center studies in several countries on both men or women shows the necessity for additional reversible male contraceptive methods. Results from recent surveys clearly indicate that there is a market and a need for novel pharmaceutical preparations for male contraception.  

Keywords: Male Contraception, Contraceptive agents, Hormonal methods

Copyright@2002-2010. Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City. All rights reserved.

Powered by Poracom E-mail: jmanager@poracom.net