Tropical Journal of Pharmaceutical Research

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Case Report

Pancytopenıa and Sepsıs due to Meropenem: A Case Report

Muzaffer Erden, Erim Gulcan^*, Arzu Bılen, Yusuf Bılen, Abdullah Uyanık and Mustafa Keleş²

Department of Internal Medicine, M.D. Ataturk University School of Medicine, Central Campus, Erzurum, Turkey

*For correspondence: Email: drerimgulcan@gmail.com Tel: +90 505 6887688,

Received: 26 January 2012 Revised accepted: 29 November 2012

Tropical Journal of Pharmaceutical Research, February 2013; 12(1): 127-129

http://dx.doi.org/10.4314/tjpr.v12i1.21

Abstract

Meropenem is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with meropenem are rare with an incidence of 1 %. Recently we came across two rare adverse effects of meropenem in one patient with acute renal failure. There was pancytopenia and sepsis, respectively. To the best of our knowledge, a only few cases have been reported in the literature that document an association between meropenem administration and pancytopenia, and about half of these cases were sepsis. With the use of meropenem becoming more widespread, these two rare but fatal complications of meropenem should be borne in mind.

Keywords: Meropenem, Pancytopenia, Sepsis, Fatal complications