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Original Research Article
Optimization of
Finasteride Nano-Emulsion Preparation Using Chemometric
Approach
Soheila Honary1*,
Pouneh Ebrahimi2 and Mahshid Nikbakht1
1Mazandaran University of
Medical Sciences, School of Pharmacy, Sari, 2Department
of Chemistry, Gonbad Kavous University, PO Box 163,
Gonbad, Iran
*For
correspondence: Email:
Shonary@yahoo.com or
honary@ualberta.ca
Received: 5 September 2012
Revised accepted: 4 June
2013
Tropical Journal of
Pharmaceutical Research, August 2013;
12(4): 457-460
http://dx.doi.org/10.4314/tjpr.v12i4.2
Abstract
Purpose: To study the effect of some factors on the
size of finasteride nano-emulsion by
chemometric approach which could predict the
size of nano-emulsion droplets under
different conditions.
Methods: Nano-emulsions were prepared using spontaneous
emulsification method which occurs when organic and
aqueous phases are mixed. The organic phase was a
homogeneous solution of oil (finasteride as a lipophilic
drug) and water�miscible solvent with or without
lipophilic surfactant (Span� 80), while the
aqueous phase consisted of water with or without
hydrophilic surfactant (Tween� 80).
Chemometric approach was applied for optimizing the size
of the nano-emulsion droplets. For this purpose, the
effect of three experimental parameters on size was
investigated by multivariant analysis. The experiments
were performed according to Box-Behnken experimental
design. The factors considered were sonication time (0 �
5 min), and contents of Span-80 (0 - 0.16 %) and
Tween-80 (0 - 0.26 %).
Results: The regression model obtained was characterized
by both descriptive and predictive ability. The method
was optimized with respect to average diameter as a
response, based on a defined equation
Conclusion: The Box-Behnken experimental design is a suitable
tool for optimizing and testing the robustness of the
method for preparing finasteride nano-emulsion.
Keywords:
Box-Behnken experimental design, Optimization,
Nanoemulsion, Finasteride. |
