Formulation and In
vitro Evaluation of Carvedilol Transdermal Delivery
System
Pisipati Aparna1*,
Lyadella Divya1, Kalva Bhadrayya2,
Chavali VS Subrahmanyam1
1Department of Pharmaceutics,
Osmania University,
Gokaraju Rangaraju College of
Pharmacy, Jawaharlal Nehru Technological University,
Hyderabad, 2Swaroop Tech Consultancy,
Secunderabad, India.
*For correspondence:
Email:
aparna_16p@hotmail.com
Received: 10 April 2013
Revised accepted: 30 June 2013
Tropical Journal of
Pharmaceutical Research, August 2013;
12(4): 461-467
http://dx.doi.org/10.4314/tjpr.v12i4.3
Abstract
Purpose: To develop and optimize
carvedilol transdermal delivery system.
Methods: Solvent casting method was
used to prepare patches using polymethyl methacrylate (PMMA)
and Eudragit E100 (EE100) polymers, dimethylsulfoxide (DMSO)
penetration enhancer, dibutylphthalate (DBP) plasticizer
and Tween 80 surfactant. A 23 factorial
design was used based on three variables (PMMA, EE100,
DMSO). at two levels Second order polynomial equations
indicating interplay of ingredients were obtained by
factorial design using SigmaTech software for 1, 4, 8
and 20 h release data. so the design was extended to
central composite design (CCD). The target formulation
was obtained from contour plots and evaluated for
various physicochemical parameters. including in-vitro
dissolution studies.
Results: Curvature effect was
observed in F1 to F8 formulations, highlighting the
interplay of ingredients. The interaction term (X2X3)exhibited
highest Sum of Squares SS ratio at 1, 4, and 8 h data
with positive coefficients indicating interaction; and
so extended to CCD. From contour plots target
formulation, F19, was identified and evaluated. The
release data, were subjected to kinetic analysis, which
followed Higuchi (diffusion) model (R2 =
0.9886).
Conclusion: F19 yielded release profile
nearer to the theoretical predictions with R2
of 0.9888 and followed Higuchi kinetics. Thus, a
diffusion-mediated carvedilol matrix patch was
successfully developed.
Keywords: Carvedilol, Central
composite design, Drug release, Transdermal patch.
