Sensitivity and
Responsiveness of Health Utility Indices (HUI2 and HUI3)
Among Type 2 Diabetes Patients
Maxwell Ogochukwu Adibe*
and Cletus Nze Aguwa
Pharmaceutical Outcomes
Research Team, Department of Clinical Pharmacy and
Pharmacy Management, Faculty of Pharmaceutical Sciences,
University of Nigeria, Nsukka, Nigeria
*For correspondence:
Email:
Maxwell.adibe@gmail.com;
maxwell.adibe@unn.edu.ng;
Tel: +234 803 778 1479
Received: 5 October
2012
Revised accepted:
22 June 2013
Tropical Journal of
Pharmaceutical Research, October 2013;
12(5):
835-842
http://dx.doi.org/10.4314/tjpr.v12i5.26
Abstract
Purpose: To assess the sensitivity
and responsiveness of HUI2 and HUI3 among Type 2
diabetes patients.
Methods: This cross-sectional study
was conducted in two purposively selected Nigerian
tertiary hospitals. Six hundred and thirty-eight (638)
adult patients were surveyed following their consent
using the HUI2 and HUI3 (HUI23S4En.40Q) questionnaire.
Patients’ clinical characteristics such as age,
co-morbidity, severity of disease, and utilization of
hospital resources were postulated a priori to be
associated significantly with utility scores of HUI2 and
HUI3. Student’s t-test and bivariate analyses were
conducted to determine the diabetes-severity
discriminatory ability of HUI2 and HUI3. The analyses
were conducted with SPSS 14.0. A two-tailed significance
level of 0.05 was used.
Results: Older patients had lower
quality of life than younger patients. The overall
health deficit of increasing age for HU13 was -0.2950
and that of overall HUI2 was -0.1553. The respondents
without eye problem had higher quality of life than
those with eye problem, in both HUI3 and HUI2 utility
scores. Stroke was the most important patients’
characteristic that negatively affected HRQOL. Patients
with duration of diabetes > 4 years had lower quality of
life scores than their counterparts (≤ 4years).
Conclusion: Health Utility Index Mark 2
and Mark 3 were sufficiently sensitive and responsive to
diabetes severity among Type 2 diabetes patients.
Keywords:
Health utility index, HUI2, HUI3, Quality of life,
Diabetes
