Association of Biochemical
Markers, Hepatitis C Virus and Diabetes Mellitus in
Pakistani Males
Muhammad Faisal Bashir1,
2, Muhammad Saleem Haider3*,
Naeem Rashid1 and Saba Riaz2,4
1School of Biological
Sciences, University of the Punjab, Lahore 54590, 2Division
of Molecular Pathology, Citi lab and Research Centre,
525 A Faisal Town, Lahore, 3Institute of
Agricultural Sciences, 4Department of
Microbiology and Molecular Genetics, University of the
Punjab, Lahore 54590, Pakistan.
*For correspondence:
Email:
haider65us@yahoo.com,
sabbb1502@yahoo.com; Tel:
+9242 99231846
Received:
26 December 2012
Revised accepted:
4 June 2013
Tropical Journal of
Pharmaceutical Research, October 2013;
12(5):
845-850
http://dx.doi.org/10.4314/tjpr.v12i5.27
Abstract
Purpose:
To investigate the
association between Hepatitis C Virus (HCV) infection
and diabetes mellitus (DM), and the effects of these
pathological conditions on some biochemical markers in
Pakistanis.
Methods: A total number of 4717
chronic HCV patients were enrolled in this study out of
which 4250 were positive with the enzyme linked
immunosorbant assay (ELISA). Out of this, HCV was
detected in 3513 samples by qualitative polymerase chain
reaction (PCR). PCR positive samples were divided into:
HCV without diabetes ( n = 3136) and HCV with diabetes (
n = 377) groups; 130 patients with diabetes only
(negative for HCV ELISA) were also included in the
study. Biochemical tests of all three groups were
performed to determine liver, diabetic and lipid
profiles.
Results: There was increased
prevalence of HCV alone and HCV + diabetes patients in
the 4th decade of life. Alanine
aminotransferase (ALT) titers were higher in HCV
patients with diabetes than in HCV patients without
diabetes (p ≤ 0.001). Fasting blood glucose was greater
in HCV patients with diabetes than in diabetes only
patients. Total cholesterol and triglyceride were
moderately lower in non-diabetic HCV patients than in
diabetes only patients (p ≤ 0.005). However, total
cholesterol and triglyceride levels were significantly
higher in HCV patients with diabetes than in the other
two groups (p ≤ 0.001).
Conclusion: There is positive
correlation of HCV with diabetes in the population
studied. This association is more pronounced (where
there are elevated levels of triglyceride and fasting
blood glucose) in HCV patients with diabetes than
diabetes patients without HCV infection.
Keywords:
Hepatitis C, Diabetes
mellitus, Biochemical markers, Lipid profile,
Glycosylated haemoglobin
