Antioxidative Activities of
Natural Hydroxy-Bearing
Cinnamaldehydes and Cinnamic Acids: A
Comparative Study
Hong Jiang2,
Sheng-Ling Sun3, Chao Zhang2,
Erdong Yuan1, Qing-Yi Wei1*, Zhen
Zeng2
1College of Light Industry and
Food Science, South China University of Technology,
Guangzhou 510640, 2Department of Chemistry,
College of Science, Huazhong Agricultural University,
Wuhan 430070, 3State Key Laboratory of
Isotope Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou
510640, China.
*For correspondence:
Email:
feweiqingyi@scut.edu.cn;
Tel: +86-020-87112594; Fax:
+86-020-87112594
Received: 2 November 2013
Revised accepted: 9 October 2013
Tropical Journal of
Pharmaceutical Research, December 2013;
12(6): 1017-1022
http://dx.doi.org/10.4314/tjpr.v12i6.22
Purpose: To determine the potent
antioxidants among six hydroxy-bearing cinnamaldehyde
compounds and their corresponding acids.
Methods: The
antioxidative activities were evaluated by scavenging
2, 2’-diphenyl-1-picrylhydrazyl (DPPH) free
radicals and anti-hemolysis of human red blood cells (RBCs).
Fourier transform infrared spectrometry(FT-IR, nuclear
magnetic resonance (NMR)and mass spectrometer(MS)
evaluations were used to determine the
synthesized compounds.
Results: The scavenging ability of the
compounds on DPPH radicals was in the following rank
order: caffeic aldehyde (F) ≈ caffeic acid (C)
> vitamin C (Vc) > o-coumaraldehyde (D)
> p-coumaric acid (B) >
p-coumaraldehyde (E) ≈o-coumaric acid. Inhibitory
ability against 2′-Azobis(2-methylpropionamidine)
dihydrochloride (AAPH)-induced erythrocyte hemolysis was
ranked as follows: o-coumaraldehyde (D) > p-coumaraldehyde
(E) ≈ caffeic aldehyde (F) > caffeic acid
(C) ≈o-coumaric acid (A) > p-coumaric
acid (B) > Vitamin C. The corresponding
inhibition time (tinh ) of D and Vc was 63.6, and 23.7 min,
respectively.
Conclusion: Cinnamaldehydes demonstrated
superior antioxidative activities to their corresponding
acids. DPPH scavenging ability correlated directly with
the number of hydroxyl groups on the catechol ring while
the degree of lipophilicity of the compounds may be
proportional to their anti-hemolytic activity.
Keywords:
DPPH scavenging, Cinnamaldehyde, Cinnamic acid,
Antioxidative, Hemolysis.