Abstract
Purpose: To develop and
validate simple, rapid and sensitive spectrophotometric
procedures for determination of trimipramine in tablet
dosage form.
Methods: The methods were
based on the interaction of trimipramine as n-electron
donor with the s-acceptor, iodine
and various p-acceptors, namely:
chloranil (CH), chloranilic acid (ChA), 2,3-dichloro-5,
6-dicyano-1, 4-benzoquinone (DDQ), and 7, 7,8, 8
tetracyanoquinodimethane (TCNQ), to form charge transfer
complexes. The complexes obtained were measured
spectrophotometrically at 292, 220, 520, 302, and 824 nm
for I2, CH, ChA, DDQ, and TCNQ, respectively.
Different variables affecting the reaction were
carefully studied and optimized.
Results:
Beer's law was obeyed over the concentration ranges 1 -
5, 5 - 50, 15 - 100, 5- 50, and 10 -75 ppm for I2,
CH, ChA, DDQ, and TCNQ respectively, with apparent
molar absorptivities of 7.1 ´ 104,
0.3 ´ 104,
1.6 ´ 104,
0.26 ´ 104,
and 0.1 ´ 104 l
mol-1cm-1 respectively. The
proposed methods were successfully applied to the
determination of trimipramine with good accuracy and
precision.
Conclusion: The results
demonstrated that the developed methods are as accurate,
precise and reproducible as the pharmacopeial method.
The methods would be valuable for routine application in
quality control.
Keywords:
Charge-transfer
complex, Trimipramine,
Spectrophotometry (T and S)
