Tropical Journal of Pharmaceutical Research

Indexed by Science Citation Index (SciSearch), International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index Copernicus, EBSCO, African Index Medicus, JournalSeek, Journal Citation Reports/Science Edition, Directory of Open Access Journals (DOAJ), African Journal Online, Bioline International, Open-J-Gate

ISSN: 1596-5996 (print); 1596-9827 (electronic)-

Home | Back Issues | Current Issue | Review manuscript | Submit manuscript


	This Article
	Abstract
	Full-Text (PDF)
	Table of contents
	Comments
	Letters
	Comments to Editor

	e-mail Alert
	Sign Up

Original Research Article

Physiochemical Properties of the Complex of Myricetin and Hydroxypropyl-β-Cyclodextrin

Haijuan Nan*, Hanjun Ma, Ruiting Zhang and Rui Zhan

School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China

*For correspondence: Email: nanhaijuan1@163.com

Received: 15 July 2014 Revised accepted: 16 October 2014

Tropical Journal of Pharmaceutical Research, November 2014; 13(11): 1791-1796

http://dx.doi.org/10.4314/tjpr.v13i11.3

Abstract

Purpose: To improve the hydrophilic property of myricetin by complexing it with hydroxypropyl-β-cyclodextrin (HP-β-CD)

Methods: The complexes of myricetin and HP-β-CD were prepared in both water and ethanol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-ray diffractometry (XRD).

Results: The content of myricetin in the complex prepared in ethanol (3.71 %) was higher than that prepared in water (1.43 %). Characterization studies indicate that myricetin in the complex was molecularly dispersed in HP-β-CD matrix.

Conclusion: Ethanol is the better solvent to prepare the complex of myricetin and hydroxypropyl-β-cyclodextrin. Myricetin and HP-β-CD in the complex are combined by non-covalent bond, and thus did not form a new compound.

Keywords: Myricetin, Hydroxypropyl-β-cyclodextrin, Complexation, Physicochemical properties