Purpose: To formulate and evaluate
sustained-release indomethacin tablets based on
solidified reverse micellar solution (SRMS).
Methods: SRMS consisting of
mixtures of phospholipid (Phospholipon® 90H)
and triglyceride (Softisan® 154) were
prepared in the ratios of 1:1, 2:1 and 1:2,
respectively. SRMS-based tablets containing 75 mg of
indomethacin each were prepared using a validated
plastic mould. The physicochemical properties of the
tablet formulations were studied. In vitro release study
was carried out in simulated intestinal fluid (SIF, pH
7.5).
Results:
The results showed that the
physicochemical properties of the tablet formulations
were significantly affected by the composition/ratio of
the lipid matrix used (p < 0.05). Tablet hardness ranged
from 5.00 ± 0.39 to 5.60 ± 0.36 kgf for tablets
formulated with SRMS 1:2 and 2:1 (N3 and N2),
respectively. The tablets exhibited friability of < 1 %
(p < 0.05). Erosion time in SIF ranged from 124.0 ± 0.5
to 180.0 ± 1.1 min while drug release from the tablets
reached a maximum in 8 – 11 h for all the batches.
Conclusion:
Indomethacin tablets based
on SRMS exhibited good sustained-release properties and
can be further developed to achieve once daily
administration for improved patient adherence to
therapy.
Keywords: Solidified reverse
micellar solution, Phospholipid, Triglyceride,
Indomethacin, Sustained release.
