Factors Associated with
Treatment Response to Antidiabetic Agents in Compliant
Type 2 Diabetes Mellitus Patients: A Brief Summary of
5-Year Data
Hasniza Zaman Huri1,2*
and Lee Tze Xiang2
1Clinical Investigation
Centre, Faculty of Medicine,13th Floor Main
Tower, University Malaya Medical Centre, 59100 Lembah
Pantai Kuala Lumpur, 2Department of Pharmacy,
Faculty of Medicine, University of Malaya, Kuala Lumpur
50603, Malaysia
*For correspondence:
Email:
hasnizazh@um.edu.my, hasnizazh@ummc.edu.my
Tel: +603 79676657
Fax: +603 79674964
Received: 6 March 2013
Revised accepted: 11
January 2014
Tropical Journal of
Pharmaceutical Research, March 2014;
13(3):
429-435
http://dx.doi.org/10.4314/tjpr.v13i3.18
Abstract
Purpose:
To
evaluate the response to diabetic medications and
factors influencing drug response in compliant type 2
diabetes mellitus (T2DM) patients.
Methods:
A
cross-sectional, retrospective study was performed on
100 T2DM patients at the University Malaya Medical
Centre (UMMC) who were prescribed with at least one
antidiabetic medication between January 2007 and
December 2011.
Results:
Using data from their medical records, it was determined
that both fasting plasma glucose (FPG) and glycated
hemoglobin (A1c) levels among all subjects were lower
than baseline values. However, the reductions were not
significant (p = 0.239 and p = 0.093). Factors that were
significantly associated with the response to diabetic
medications, include hypertension (p = 0.011),
sulfonylureas (p = 0.041), beta-blockers (p = 0.005),
and baseline A1c levels (p < 0.001).
Conclusion:
Treatment of T2DM can be further optimized to ensure
that diabetes is well-controlled.
Keywords:
Treatment response; Antidiabetics;
Type 2 Diabetes Mellitus, Hypertension, Beta-blocker
.
