Tropical Journal of Pharmaceutical Research

Indexed by Science Citation Index (SciSearch), International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index Copernicus, EBSCO, African Index Medicus, JournalSeek, Journal Citation Reports/Science Edition, Directory of Open Access Journals (DOAJ), African Journal Online, Bioline International, Open-J-Gate

ISSN: 1596-5996 (print); 1596-9827 (electronic)-

Home | Back Issues | Current Issue | Review manuscript | Submit manuscript


	This Article
	Abstract
	Full-Text (PDF)
	Table of contents
	Comments
	Letters
	Comments to Editor

	e-mail Alert
	Sign Up

Review Article

Nasal Inserts for Drug Delivery: An Overview

Evren Algın-Yapar

The Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, Sögütözü Mahallesi 2176. Sokak No:5, 06520 Çankaya Ankara, Turkey.

*For correspondence: Email: evren.yapar@yahoo.com, algin@pharmacy.ankara.edu.tr Tel: +90. 532. 382 56 86; Fax: +90. 312. 218 35 85

Received: 18 December 2013 Revised accepted: 19 February 2014

Tropical Journal of Pharmaceutical Research, March 2014; 13(3): 459-467

http://dx.doi.org/10.4314/tjpr.v13i3.22

Abstract

Nasal mucosa, owing to its high vascularity and thin epithelial membrane, has been widely explored for drug administration in the last two decades. Within that period various nasal dosage forms have been researched and developed. Among them, nasal inserts are easily prepared by lyophilization or gelsification, allow easy dosing with a high potential for systemic administration, enable avoidance of hepatic first pass metabolism, and make possible the release of active ingredient in a controlled manner. In this review, the benefits, limitations and absorption mechanisms of the nasal route, as well as findings from nasal insert-related studies are addressed.

Keywords: Nasal drug delivery, Insert, Mucoadhesion, Absorption, Lyophilization, Gelsification.