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Original Research Article
Development of
Sustained-Release Microbeads of Nifedipine and In
vitro Characterization
Sajid Bashir1,
Muhammad Asad1,2, Sumbul Qamar1*,
Fakhar ul Hassnain1, Sabiha Karim3
and Imran Nazir1,4
1Faculty of Pharmacy,
University of Sargodha, Sargodha 40100, 2The
University of Faisalabad, Faisalabad 38000, 3College
of Pharmacy, University of Punjab, Lahore 54000, 4Department
of Pharmacy, COMSATS Institute of Information
Technology, Abbottabad 22060, Pakistan
*For correspondence:
Email:
drsumbul06@gmail.com; Tel:
+923336775523; Tel: +92992383441
Received: 4 April 2013
Revised accepted: 18
February 2014
Tropical
Journal of Pharmaceutical Research, April 2014;
13(4):
505-510
http://dx.doi.org/10.4314/tjpr.v13i4.3
Abstract
Purpose: To formulate and evaluate
sustained-release microbeads of nifedipine for prolonged
delivery.
Methods: Nifedipine microbeads were
prepared using sodium alginate and pectin in different
ratios by ionic-gelation method. The microbeads were
evaluated for surface morphology and shape by scanning
electron microscopy (SEM), micromeritic properties,
microencapsulation efficiency and in vitro drug release.
The microbeads were also assessed by Fourier Transform
Infra-red Spectroscopy (FTIR) and differential scanning
calorimetry (DSC) to determine drug-polymer interaction,
if any.
Results: FTIR and DSC results
indicate absence of interaction between the drug and
polymers used. Good rheological behavior was
demonstrated with an angle of repose < 30º, and Carr’s
index and Hausner’s ratio of < 10% and < 1.12,
respectively Microbead size, yield and entrapment
efficiency were in the range of 695 to 733 um, 69 to 75%
and 54 to 63%, respectively. SEM revealed that the
microbeads were discrete, largely spherical and
free-flowing. Higuchi model was the best fit for the
dissolution data and followed non-Fickian diffusion
mechanism.
Conclusion: The microbead formulation
would be suitable for sustained release of nifedipine.
Keywords: Microbead, Nifedipine,
Alginate, Ionic gelation, Pectin, Higuchi model, Non-Fickian
diffusion. |
