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Original Research Article
Natural Borneol Recycling
from Cinnamomum camphor chvar. Borneol Oil
Residue by Fractional Distillation and Recrystallization
Xiao Ying Chen1,
Xiao Ning Zhao2, Hui Fang Zeng2,
Jian Hui Xie1,3, Xiao Lu Chen2,
Yong Zhuo Liang1, Qi Duan Wu2, Zi
Ren Su1,5, Hong Feng Wang4* and
Xiao Ping Lai1,5*
1School of Chinese Materia
Medica, Guangzhou University of Chinese Medicine,
Guangzhou 510006, 2The First Affiliated
Hospital of Chinese Medicine, Guangzhou University of
Chinese Medicine, Guangzhou 510405, 3The
Second Affiliated Hospital of Chinese Medicine,
Guangzhou University of Chinese Medicine, Guangzhou
510405, 4Biotechnology Division, Guangdong
Academy of Forestry, Guangzhou, 5Dongguan
Mathematical Engineering Academy of Chinese Medicine,
Guangzhou University of Chinese Medicine, Dongguan,
523808, China
*For correspondence:
Email:
lxp88@gzucm.edu.cn,
wanghf@sinogaf.cn; Tel:
+86-20-39358517; Fax: +86-20-39358390
Received: 10 May 2014
Revised accepted: 7 August
2014
Tropical
Journal of Pharmaceutical Research, September 2014;
13(9): 1463-1470
http://dx.doi.org/10.4314/tjpr.v13i9.12
Abstract
Purpose: To establish an efficient
method to recycle natural borneol from Cinnamomum
camphor chvar. Borneol oil residue.
Methods: The fractions and raffinate
of the oil residue of Cinnamomum camphor chvar. Borneol
were obtained by fractional distillation, and analyzed
by gas chromatography with flame ionization detector
(GC-FID) and gas chromatography- mass spectrometry
(GC-MS). Natural borneol was purified by
recrystallization and suction filtration. Fractional
distillation and recrystallization parameters, including
reflux ratio, solvent and solvent amount, were
optimized. The physicochemical properties of natural
borneol were determined by melting point and optical
rotation techniques.
Results: The total yield of natural
borneol was 7.6 % under the optimal conditions, viz,
reflux ratios of 3:1 and 1:1, with n-hexane as
recrystallizing solvent. The purity of recrystallized
natural borneol was > 99 % at the solvent ratio of 1:1.8
(natural borneol crystal : n-hexane). The optical
rotation ([α]24D = + 37�) and
melting point (207 �C) of natural borneol were in accord
with those of the standard.
Conclusion: These findings indicate
that the developed fractional distillation and
recrystallization method can be applied to recycle
natural borneol from C. camphor chvar. Borneol oil
residue.
Keywords: Cinnamomum camphora chvar.
Borneol, Oil residue, Natural borneol, Fractional
distillation, Recrystallization |
