Tropical Journal of Pharmaceutical Research | ||||||||||||||
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In-Vitro Adsorption of Fluoroquinolones on Some Pharmaceutical Adsorbents Chukwuenweniwe
J. Eboka* and Aderemi B. Afolabi Department of Pharmaceutical Chemistry, University of Benin, Benin City.
Tropical Journal of Pharmaceutical Research 2006; 5(1): 533-538 ISSN: 1596-5996
Abstract Purpose:
Drug overdose and poisoning are common clinical problems and could occur with
the fluoroquinolones – a new series of synthetic antimicrobial agents. It
therefore becomes important to study the adsorption of the fluoroquinolones on
pharmaceutical adsorbents which could serve as possible antidotes for the
emergency treatment of fluoroquinolone overdose or poisoning when they occur. Method:
The rate and extent of adsorption of the fluoroquinolones on some pharmaceutical
adsorbents, namely activated charcoal, kaolin and bentonite were investigated
spectrophotometrically Results: The
fluoroquinolones adsorbed on activated charcoal rapidly and attained equilibrium
within fifteen minutes. The fluoroquinolones however adsorbed on kaolin and
bentonite less rapidly and attained equilibrium within two hours. Activated
charcoal and bentonite had high adsorption capacities for the fluoroquinolones
while kaolin had low adsorption capacities for them. Keywords: Adsorption, bentonite, fluoroquinolones, kaolin, pharmaceutical adsorbents To whom correspondence should be addressed: E-mail: chukeboka@yahoo.com
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Last updated: August 30, 2006 |