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Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced Hepatotoxicity Nadro
M.S., Arungbemi R.M. and *Dahiru D. Department of Biochemistry Federal University of Technology, Yola P.M.B. 2076, Yola, Nigeria
Tropical Journal of Pharmaceutical Research 2006; 5(1): 539-544 ISSN: 1596-5996
Abstract A study on the
protective effect of Moringa oleifera leaf extract in acute alcohol-induced
hepatotoxicity in rats was evaluated. Rats fed alcohol only produced significant
increase in the levels of enzyme markers of tissues damage (ALT, AST and ALP),
lipid peroxidation (TBARS) and decreased serum vitamin C levels compared to
normal control rats. Pretreatment with 100 and 200mg/kg body weight of extract
significantly decreased the levels of enzyme markers, lipid peroxidation and
markedly increased serum vitamin C level in a dose-dependent manner.
Post-treatment with 200mg/kg body weight of extract significantly enhanced the
recovery of animals from hepatic damage compared to untreated control. Lipid
peroxidation and depletion of vitamin C due to oxidative stress could be the
possible mechanisms of alcohol induced toxicity and the protective effect of the
extract could be as a result of its ability to inhibit lipid peroxidation and
prevent the depletion of vitamins C. To whom correspondence should be addressed: E-mail: ddahiru2000@yahoo.com
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Last updated: August 30, 2006 |